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Precautions and Warnings With Febuxostat

To help ensure a safe and effective treatment process, make sure you are aware of the precautions and warnings with febuxostat. Before taking this medication, let your healthcare provider know of any other medical conditions you have, such as liver or kidney disease. It also may not be safe to use febuxostat if you are pregnant or breastfeeding, or if you have certain allergies.

What Should I Tell My Healthcare Provider Before Taking Febuxostat?

You should talk with your healthcare provider prior to taking febuxostat (Uloric®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Febuxostat Precautions and Warnings

Some warnings and precautions to be aware of prior to taking febuxostat include the following:
  • In some early studies, people taking febuxostat seemed to have a higher risk for heart attacks or strokes. This was not seen in a larger, later study, and there is no logical reason why febuxostat would cause such problems. Nonetheless, make sure to watch for any heart attack symptoms or stroke symptoms, and seek immediate medical attention if you suspect either of these problems.
  • Febuxostat works to prevent gout attacks; it does not help treat attacks that are already occurring. In fact, it can temporarily worsen gout, especially at first. For these reasons, febuxostat is usually used along with other gout medications, especially for the first few months.
  • Febuxostat can increase liver enzymes. While an increase in liver enzymes does not necessarily mean there is any problem, it could also be an indicator of liver damage. Your healthcare provider should monitor your liver enzymes periodically (using a simple blood test).
  • Febuxostat could potentially interact with other medications (see Drug Interactions With Febuxostat).
  • Febuxostat is considered a pregnancy Category C medication. This means that febuxostat may not be safe to use during pregnancy. Talk to your healthcare provider about the risks and benefits of using febuxostat during pregnancy (see Uloric and Pregnancy for more information).
  • It is not known if febuxostat passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, make sure to talk with your healthcare provider about using febuxostat (see Uloric and Breastfeeding).
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