Drug Interactions With Febuxostat
Febuxostat could substantially increase the level of mercaptopurine in your blood, increasing the risk of side effects of mercaptopurine. These medications should not be taken together.
Febuxostat could substantially change the way your body metabolizes theophylline, potentially exposing the body to very high levels of 1-methylxanthine, which is one of the compounds that theophylline can be broken down into. The effects of long-term exposure to high levels of 1-methylxanthine are unknown. Talk with your healthcare provider before taking theophylline and febuxostat together.