Drug Interactions With Extended-Release Gabapentin

If you take extended-release gabapentin with alcohol, aluminum-containing antacids, morphine, or certain other medications, it can change the way your body metabolizes these products. As a result, the effectiveness of the medications may be decreased or your risk for side effects may be increased. To minimize negative interactions with extended-release gabapentin, tell your healthcare provider about any other drugs, vitamins, or supplements you are taking.

Gabapentin ER Drug Information

An Overview of Extended-Release Gabapentin Interactions

Extended-release gabapentin (Gralise™) may react with many other medications. Some of the drugs that may lead to extended-release gabapentin interactions include but are not limited to:

Alcohol
Antacids containing aluminum or magnesium (such as Phillips'^® Milk of Magnesia, Maalox^®, or Gaviscon^®)
Hydrocodone (such as Lortab^®, Norco^®, Vicodin^®)
Morphine (Avinza^®, MS Contin^®, MSIR^®, Oramorph SR^®, Roxanol^®)
Naproxen (Aleve^®, Anaprox^®, Naprelan^®, Naprosyn^®).

Drug Interactions With Extended-Release Gabapentin Explained

The following sections explain in detail the potentially negative reactions that can occur when extended-release gabapentin is combined with any of the drugs listed above.

Alcohol

Alcohol can increase your risk for certain extended-release gabapentin side effects, such as drowsiness or dizziness. Talk to your healthcare provider about drinking alcohol while taking extended-release gabapentin.

Aluminum or Magnesium Antacids

Antacids that contain aluminum or magnesium can decrease the absorption of extended-release gabapentin into your bloodstream, perhaps making it less effective. In order to avoid this interaction, do not take these medications within two hours of each other.

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