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Drug Interactions With Extended-Release Gabapentin

Hydrocodone
Taking extended-release gabapentin with hydrocodone can decrease the level of hydrocodone and increase the level of extended-release gabapentin in your blood. Also, taking these medications together could increase your risk for certain side effects, such as dizziness or drowsiness. Talk to your healthcare provider before using these medications together.
 
Morphine
Morphine can increase the level of extended-release gabapentin in your blood, increasing your risk for extended-release gabapentin side effects. Talk to your healthcare provider before taking these medications together, as you may need a lower extended-release gabapentin dosage.
 
Naproxen
Naproxen seems to increase the amount of extended-release gabapentin absorbed into your bloodstream, possibly increasing the risk for extended-release gabapentin side effects. Talk to your healthcare provider before taking these medications together.
 

Final Thoughts

Extended-release gabapentin can potentially interact with many other drugs, and it is possible that not all of these interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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