Etidronate dosing is determined by several factors, including your weight, existing conditions you may have, and other medications you're taking. For preventing or treating heterotopic ossification due to total hip replacement surgery or spinal cord injury, the recommended dose is 20 mg per kg of body weight once daily. The suggested etidronate dosage for treating Paget's disease is 5 mg per kg of body weight once a day.
The dose of etidronate disodium (Didronel®) that your healthcare provider recommends will vary depending on a number of factors, including:
- Your weight
- The medical condition being treated
- Other medications you may be taking
- Other medical conditions you may have.
As is always the case, do not adjust your etidronate dose unless your healthcare provider specifically instructs you to do so.
Heterotopic ossification is bone formation in abnormal areas (such as in muscle). The recommended etidronate dose for preventing or treating heterotopic ossification due to total hip replacement surgery is 20 mg per kg of body weight (about 9 mg per pound) once daily, started one month before surgery and continuing for three months after surgery (for a total of four months).
The recommended etidronate dose for preventing or treating heterotopic ossification due to spinal cord injury is 20 mg per kg of body weight (about 9 mg per pound) once daily starting as soon as possible after the injury. After two weeks, the dose should be reduced to 10 mg per kg (about 4.5 mg per pound) once daily for 10 weeks (for a total of 12 weeks).
Since etidronate will not impair the healing after total hip replacement or spinal cord injury, there is no need to delay treatment until healing has occurred.