The recommended starting etidronate dose for treating Paget's disease of bone is 5 mg per kg of body weight (about 2.3 mg per pound) once daily for up to six months. If necessary, your healthcare provider may increase your dose up to 20 mg per kg (about 9 mg per pound) once daily. Etidronate doses higher than 10 mg per kg (about 4.5 mg per pound) should be given for a shorter period of time (three months or less).
If necessary, you may be retreated with etidronate after at least 90 days after the initial treatment.
Considerations for people taking etidronate include the following:
- The medication comes in tablet form. It is taken by mouth every day for a period of time (usually three to six months, depending on several factors).
- Take etidronate on an empty stomach first thing in the morning. Do not eat for two hours before or after taking the drug. Many foods interact with etidronate, decreasing its absorption into the body (making it less effective).
- Swallow etidronate tablets whole with a full glass of plain water (not any other beverage).
- Try to stay upright for 30 minutes after taking etidronate, as this can help prevent irritation to your esophagus.
- Do not take vitamins, minerals, or antacids that contain calcium, iron, magnesium, or aluminum for two hours after taking etidronate (see Drug Interactions With Etidronate).
- It is best to take etidronate at the same time each day to maintain an even level of the medication in your blood.
- For the medication to work properly, it must be taken as prescribed.
- If you are unsure about anything related to etidronate or your etidronate dosage, please talk with your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.