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Drug Interactions With Diclofenac Sodium Topical Solution

When heparin, ibuprofen, or certain cosmetics are combined with diclofenac sodium topical solution, drug interactions can occur. These interactions can increase your risk of side effects and put you at risk for kidney damage, among other things. Telling your healthcare provider about all the medications you are currently taking will help ensure your safety and reduce your risk of problems.

An Overview of Diclofenac Sodium Topical Solution Interactions

Even though diclofenac sodium topical solution (Pennsaid®) is applied to the skin, it can potentially react with several other medications, since some of the topical solution is absorbed into the bloodstream. Some of the drugs that may lead to interactions with diclofenac sodium topical solution include:
  • Angiotensin II receptor blockers (ARBs), such as:


  • Corticosteroids, including (but not limited to):
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
Several herbal and nutritional supplements can also interact with diclofenac sodium topical solution and may increase the risk of bleeding. Examples of these include, but are not limited to:
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Diclofenac Sodium Topical Solution Information

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