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Drug Interactions With Diclofenac Sodium Topical Solution

Diuretics
Combining diclofenac sodium topical solution with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Using diclofenac sodium topical solution and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining diclofenac sodium topical solution with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine diclofenac sodium topical solution with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Diclofenac sodium topical solution may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of diclofenac sodium topical solution in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
Skin Products
If you want to apply any other skin product on the skin where Pennsaid was applied, you must wait until Pennsaid is completely dry first.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with diclofenac sodium topical solution may increase the risk of bleeding. Check with your healthcare provider before using diclofenac sodium topical solution with an SSRI or SNRI.
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Diclofenac Sodium Topical Solution Information

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