Depo-Testosterone Drug Interactions

Before beginning treatment with Depo-Testosterone, make sure your healthcare provider is aware of any other prescription and nonprescription medications, vitamins, or supplements you are taking. Drug interactions can occur when Depo-Testosterone is combined with insulin, corticosteroids, warfarin, or several other medicines. Some of these reactions may increase your risk for problems, including fluid retention, liver damage, or bleeding.

An Overview of Interactions With Depo-Testosterone

Depo^®-Testosterone (testosterone cypionate) may react with several other medications. Some of the drugs that may cause interactions with Depo-Testosterone include but are not limited to:

Insulin of any kind
Corticosteroids, such as:

- Betamethasone (Celestone^®)
- Cortisone
- Dexamethasone (Decadron^®)
- Fludrocortisone (Florinef^®)
- Hydrocortisone (Cortef^®)
- Methylprednisolone (Depo-Medrol^®, Medrol^®)
- Prednisolone (Orapred^®, Pediapred^®)
- Prednisone
- Triamcinolone (Kenalog^®, Aristospan^®)

Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Warfarin (Jantoven^®, Coumadin^®).

Depo-Testosterone Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Depo-Testosterone is combined with any of the drugs listed above.

Insulin

Depo-Testosterone can decrease blood sugar levels. If you take insulin, you should monitor your blood sugar levels more closely when starting or stopping Depo-Testosterone, or even when adjusting your dose. You may need to adjust your insulin dose. Check with your healthcare provider for more specific instructions for your particular situation.

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