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Side Effects of Denosumab

Although most people tolerate denosumab well, side effects are possible and may include back pain, skin reactions, and high cholesterol. In most cases, reactions to this medication are mild and either don't require medical attention or are easily treated. There are, however, certain problems that should be reported to a healthcare provider immediately, including jaw or tooth problems, confusion, or difficulty breathing.

An Introduction to Denosumab Side Effects

As with any medicine, denosumab (Prolia®, Xgeva®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible denosumab side effects. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Denosumab

Some side effects with denosumab, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Frequent, persistent, or severe infections
  • Shortness of breath 
  • New or unusual thigh, hip, or groin pain, which may be symptoms of a broken femur 
  • Symptoms of low calcium levels in the blood (hypocalcemia), such as:
    • Spasms or twitches
    • Tingling in the fingers or toes
    • Depression or irritability
    • Confusion
    • An irregular heart rhythm (arrhythmia)
  • Jaw or tooth problems
  • Signs of an allergic reaction, including:
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing.
Calcium and Strong Bones

Denosumab Drug Information

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