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Drug Interactions With Denosumab

Although it is not known if there are any specific medications that react with denosumab, it is thought that complications could occur if this osteoporosis medicine is combined with certain immunosuppressants. Some of the drugs that may cause interactions with denosumab might include cyclosporine, azathioprine, and corticosteroids. Before receiving denosumab, inform your healthcare provider about any other medicines you are taking.

An Overview of Denosumab Interactions

Denosumab (Prolia®, Xgeva®) is a prescription osteoporosis medication given as an injection under the skin. At this time, there are no clearly established drug interactions with denosumab.
 
However, this does not guarantee that denosumab will not interact with other medications; it simply reflects the fact that not enough studies have been done to determine potential drug interactions.
 
Based on certain studies that indicated denosumab might increase the risk of infections (including serious infections), it is predicted that denosumab may interact with medications that suppress the immune system, such as:
 
 
  • Corticosteroids, such as:
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®)
 
Taking denosumab with other immunosuppressants could increase the risk of serious infections. This data comes from studies of the drug for osteoporosis treatment. It is unclear if the drug increases the risk of serious infection when used to prevent cancer-related bone problems.
 
Men and Osteoporosis

Denosumab Drug Information

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