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Drug Interactions

Denosumab may interact with other medications (see Drug Interactions With Denosumab).

What If I Take an Overdose of Denosumab?

It is unknown what exactly to expect with an overdose of this medication. At this time, there have been no reported cases of an overdose. Additionally, an overdose is unlikely, as the drug is given by a healthcare provider and a single dose consists of an entire vial (or prefilled syringe).

How Does This Medication Work?

Denosumab is a manufactured antibody that is designed specifically to bind to a protein known as receptor activator of nuclear factor kappa-B ligand (RANKL). Denosumab prevents RANKL from activating the RANK receptor on the surface of osteoclast cells (as well as immature cells that will eventually become osteoclast cells). Osteoclasts are bone cells that are responsible for the breakdown of bone. Denosumab slows down the formation, activity, and survival of osteoclast cells, thereby decreasing bone breakdown.

How Effective Is It?

Denosumab has been evaluated in studies of postmenopausal women with osteoporosis. In these studies, taking denosumab (along with calcium and vitamin D) reduced the risk of vertebral fractures (broken spinal bones) by 68 percent, compared to women who took just calcium and vitamin D. Denosumab also reduced the risk of hip fractures by 40 percent. Also, women taking this medication showed increased bone mineral density, compared to the women not taking the drug.
Studies have also shown that denosumab can help prevent a variety of bone-related complications in people with cancer that has spread to the bones.
4 Tips for Healthy Bones

Denosumab Drug Information

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