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Drug Interactions With Darifenacin

Darifenacin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when darifenacin is combined with any of the drugs listed above.
Acetylcholinesterase Inhibitor Medications
Taking darifenacin with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent interactions from occurring.
Anticholinergic Drugs
Combining an anticholinergic medication with darifenacin (which is also an anticholinergic medication) can increase your risk of side effects of darifenacin, such as dry mouth, constipation, dry eyes, or difficulty passing urine.
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may increase the level of darifenacin in your blood. Your healthcare provider may recommend that you take a lower darifenacin dosage if you are taking certain antibiotics or antifungals.
Darifenacin may increase the level of flecainide in your blood, possibly leading to dangerous flecainide side effects. Check with your healthcare provider before using these medications together.
Nefazodone can increase the level of darifenacin in your blood. Your healthcare provider may recommend that you take a lower dose of darifenacin if you are taking nefazodone.
Both pramlintide and anticholinergic medications (including darifenacin) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these medications.
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