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Colcrys Drug Interactions

Colcrys Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Colcrys is taken with any of the products listed above.
 
CYP 3A4 Inhibitors
Certain liver enzymes, known as CYP 3A4 enzymes, break down ("metabolize") Colcrys. Many other medications inhibit these enzymes, increasing the level of Colcrys in the body. Some of these drugs can interact quite severely with Colcrys, and some fatalities have been reported due to such interactions.
 
Different medications vary in their ability to inhibit CYP 3A4; some are strong inhibitors, while others are weak. Medications that are both 3A4 inhibitors as well as P-glycoprotein inhibitors may be especially likely to cause serious problems.
 
Do not combine Colcrys with a CYP 3A4 inhibitor without specifically checking with your healthcare provider about this particular interaction. In many cases, a lower-than-normal Colcrys dosage may be recommended.
 
People with liver or kidney disease should never take Colcrys in combination with a strong CYP 3A4 inhibitor, even if the dose of Colcrys is reduced.
 
Digoxin
There have been reports of serious muscle breakdown (known medically as rhabdomyolysis) in people taking digoxin and Colcrys together. Check with your healthcare provider before combining these medications. If your healthcare provider recommends that you take these drugs together, seek medical advice at the first signs of muscle pain or weakness in order to prevent serious complications.
 
Fibrates
There have been reports of serious muscle breakdown (rhabdomyolysis) in people taking a fibrate and Colcrys together. Check with your healthcare provider before combining these medications. If your healthcare provider recommends that you take these drugs together, seek medical advice at the first signs of muscle pain or weakness in order to prevent serious complications.
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