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Side Effects of Carbidopa

Intolerable Carbidopa Side Effects

As time goes by, many people will begin to experience intolerable side effects of carbidopa plus levodopa. While these side effects are not usually dangerous, they often signify that it is time for your healthcare provider to reevaluate your current Parkinson's disease treatment plan. These often intolerable side effects include:
 
  • Wearing off -- the effects of carbidopa wear off earlier and earlier, with noticeable, worsening Parkinson's disease symptoms occurring before every dose of carbidopa
  • Dyskinesia -- involuntary muscle movements usually caused by increased carbidopa doses (which are used in order to reduce the wearing-off effect of carbidopa)
  • On-off -- sudden, unpredictable changes in movement, varying from typical Parkinson's movements to a complete lack of movement ("freezing"), possibly occurring several times during the day.
     
It is thought that minimizing fluctuations of carbidopa levels in the blood may help reduce these intolerable carbidopa side effects.
 

Serious Side Effects Seen With Carbidopa

Some side effects with carbidopa (plus levodopa) are potentially serious and should be reported immediately to your healthcare provider. Although most of these serious side effects are rare, a few may be common. Serious side effects include, but are not limited to:
 

 

    • High fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • Fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)

 

  • Fainting
  • Bleeding in the digestive tract
  • Intestinal ulcers (known as duodenal ulcers)
  • Low white blood cells, red blood cells, or blood platelets
  • Psychiatric problems, such as:

 

    • Hallucinations
    • Delusions
    • Paranoia
    • Agitation
    • Anxiety
    • Depression
    • Suicidal thoughts or behaviors

 

  • Seizures
  • Falling or balance problems
  • Signs of an allergic reaction, including:

 

    • Unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.

 

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Carbidopa for Parkinson's Disease

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