Drug Interactions With Carbidopa (Cont.)

Carbidopa Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when carbidopa is combined with any of the drugs listed above.
 
Antipsychotic Medications
Antipsychotics can make carbidopa (combined with levodopa) less effective. Check with your healthcare provider before taking these medications together.
 
Blood Pressure Medications
Taking carbidopa (combined with levodopa) and a high blood pressure medication together can increase the risk of low blood pressure (hypotension). Check with your healthcare provider, as the dose of your blood pressure medicine may need to be reduced.
 
Iron
Iron can decrease the absorption of carbidopa into the body, perhaps making it less effective. Iron products should be taken at least two hours before or after any carbidopa doses.
 
Isoniazid
Isoniazid can make carbidopa (combined with levodopa) less effective. Check with your healthcare provider before taking these medications together.
 
Metoclopramide (Reglan)
Metoclopramide can make carbidopa (combined with levodopa) less effective. However, metoclopramide may also increase the absorption of levodopa into the body (which could make it more effective or increase the risk of carbidopa side effects). It is difficult to predict what exactly may happen if these medications are combined. Check with your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Nonselective MAOIs (isocarboxazid, phenelzine, and tranylcypromine) should not be combined with carbidopa (combined with levodopa). Selective MAOI-B inhibitors (selegiline and rasagiline) can be used with carbidopa and levodopa, although the risk of low blood pressure may be increased.
(Drug Interactions With Carbidopa Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;