Drug Interactions With Carbidopa-Levodopa CR (Cont.)

Carbidopa-Levodopa CR Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when carbidopa-levodopa CR is combined with any of the drugs listed above.
 
Antipsychotic Medications
Antipsychotic medications can make carbidopa-levodopa CR less effective. Check with your healthcare provider before combining carbidopa-levodopa with an antipsychotic medication.
 
High Blood Pressure Medications
Taking carbidopa-levodopa CR and a blood pressure medication together can increase the risk of dangerously low blood pressure (hypotension). Check with your healthcare provider, as your blood pressure may need to be monitored more closely, and you may need a lower dose of your blood pressure medicine.
 
Iron
Iron can decrease the absorption of carbidopa-levodopa CR into the body, perhaps making it less effective. Iron products should be taken at least two hours before or after any carbidopa-levodopa CR doses.
 
Isoniazid
Isoniazid can make carbidopa-levodopa CR less effective. Check with your healthcare provider before taking these medications together.
 
Metoclopramide (Reglan)
Metoclopramide can make carbidopa-levodopa CR less effective. However, metoclopramide may also increase the absorption of carbidopa-levodopa CR into the body (which could make it more effective or increase the risk of carbidopa-levodopa CR side effects). It is difficult to predict what exactly may happen if these medications are combined. Check with your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Nonselective MAOIs (isocarboxazid, phenelzine, and tranylcypromine) should not be combined with carbidopa-levodopa CR or used within two weeks of using carbidopa-levodopa CR. Selective MAOI-B inhibitors (selegiline and rasagiline) can be used with carbidopa-levodopa CR, although the risk of low blood pressure may be increased.
(Drug Interactions With Carbidopa-Levodopa CR Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;