Drug Interactions With Alendronate

Drug interactions with alendronate can occur if it is combined with aspirin, magnesium products, or a number of other medications. These interactions can increase your risk of side effects or reduce the effectiveness of alendronate. Food and beverages (other than water) can also cause drug interactions with alendronate, preventing it from being absorbed into the body and making it less effective.

 

Drug Interactions With Alendronate: An Overview

Alendronate sodium (Fosamax®) can potentially interact with a number of other medications. Many interactions can make alendronate less effective, while others may increase the risk of side effects. Some of the medicines that may lead to alendronate drug interactions include:
 
  • Aspirin
     
  • Calcium products, including many antacids
     
  • Iron supplements
     
  • Magnesium products
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as: 
 
 
Food and beverages (other than water) can also interact with alendronate, preventing it from being absorbed into the body and making it less effective. Alendronate should be taken with water in the morning on an empty stomach. Do not eat or drink anything (besides water) before taking the medication and for 30 minutes afterwards.
 
(Drug Interactions With Alendronate Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;