Drug Interactions With Alendronate (Cont.)

Alendronate Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when alendronate is combined with any of the drugs listed above.
 
Aspirin
Both aspirin and alendronate can be irritating to the stomach. Talk to your healthcare provider before taking aspirin if you are taking alendronate. Of course, no other medications (including aspirin) should be taken within 30 minutes of taking alendronate.
 
Calcium Products
Calcium binds to alendronate in the stomach, preventing it from being absorbed in the body and making it less effective. While it is usually important for people with osteoporosis to take calcium, it should not be taken within 30 minutes of taking alendronate.
 
Iron Supplements
Iron binds to alendronate in the stomach, preventing it from being absorbed in the body and making it less effective. Do not take iron supplements within 30 minutes of taking alendronate.
 
Magnesium Products
Magnesium binds to alendronate in the stomach, preventing it from being absorbed in the body and making it less effective. Do not take magnesium supplements within 30 minutes of taking alendronate.
 
Nonsteroidal Anti-Inflammatory Drugs
Both NSAIDs and alendronate can be irritating to the stomach. Talk to your healthcare provider before taking an NSAID if you are taking alendronate. Of course, no other medications (including NSAIDs) should be taken within 30 minutes of taking alendronate.
 
Teriparatide
In studies, combining teriparatide with medications like alendronate seemed to make teriparatide less effective. Talk to your healthcare provider before using these medications together.
 
(Drug Interactions With Alendronate Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;