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Side Effects of Alendronate and Cholecalciferol

Common Side Effects of Alendronate and Cholecalciferol

Most of the information known about alendronate and cholecalciferol side effects comes from studies of Fosamax® (without the vitamin D). Fosamax has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of Fosamax included:
Studies have shown that alendronate and cholecalciferol usually has similar side effects, compared with just Fosamax (without the vitamin D).

How to Minimize Side Effects of Alendronate and Cholecalciferol on the Esophagus

In order to reduce the chances of developing serious esophageal-related side effects, you should follow the prescribed directions on how to take alendronate and cholecalciferol. For example:
  • Alendronate and cholecalciferol should be taken on an empty stomach and with a full glass of water first thing in the morning.
  • Swallow the tablets whole. Do not suck or chew on them.
  • For at least 30 minutes after taking alendronate and cholecalciferol, it is important to:
    • Remain in an upright position (either sitting up or standing). In fact, you should remain upright until you have had something to eat.
    • Wait to eat or drink. This includes mineral water, sparkling water, coffee, tea, milk, or juice. Plain water is okay.
    • Avoid taking any other oral medicine, including calcium supplements.
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