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Drug Interactions With Alendronate and Cholecalciferol

Magnesium Products
Magnesium binds to alendronate and cholecalciferol in the stomach, preventing it from being absorbed in the body and making it less effective. Do not take magnesium supplements within 30 minutes of taking alendronate and cholecalciferol.
 
Nonsteroidal Anti-inflammatory Drugs
Both NSAIDs and alendronate and cholecalciferol can be irritating to the stomach. Talk to your healthcare provider before taking an NSAID if you are taking alendronate and cholecalciferol. Of course, no other medications (including NSAIDs) should be taken within 30 minutes of taking alendronate and cholecalciferol.
 
Orlistat
Orlistat can decrease the absorption of vitamin D (one of the components of alendronate and cholecalciferol) from the digestive tract, making alendronate and cholecalciferol less effective. Your healthcare provider may recommend that you take additional vitamin D to prevent this drug interaction from occurring.
 
Seizure Medications
Some seizure medications can cause your body to break down vitamin D (one of the components of alendronate and cholecalciferol) more quickly than usual. Your healthcare provider may recommend that you take additional vitamin D to prevent this.
 
Teriparatide
In studies, combining teriparatide with medications like alendronate and cholecalciferol seemed to make teriparatide less effective. Talk to your healthcare provider before using these medications together.
 
Thiazide Diuretics
Thiazide diuretics can cause your body to break down vitamin D (one of the components of alendronate and cholecalciferol) more quickly than usual. Depending on your individual situation, your healthcare provider may recommend that you take additional vitamin D.
 
Lifestyle Changes to Help Your Bones

Alendronate and Cholecalciferol for Osteoporosis

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