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Precautions and Warnings With Aflibercept

Some people may have an increased risk for retinal detachment, strokes, or a temporary increase in the pressure inside the eye while using aflibercept. This medicine may also not be safe for people who have an eye infection, certain allergies, or a history of a blood clot or stroke. Other safety precautions and warnings with aflibercept apply to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving aflibercept (Eylea™) if you have:
  • An infection in or around the eyes
  • A history of a blood clot or stroke
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Aflibercept Warnings and Precautions

Some warnings and precautions to be aware of prior to using this medicine include the following:
  • Sometimes, aflibercept injections can cause a temporary increase in the pressure inside the eye. Your healthcare provider should monitor your eyes immediately after each injection to make sure the pressure in your eye is not too high.
  • As with any injection into the eye, aflibercept can cause retinal detachment or other eye problems, although these are rare. Retinal detachment is very serious and can lead to blindness.
  • Theoretically, this medication could increase the risk for blood clots or strokes. Talk with your healthcare provider about this risk, especially if you have a history of a blood clot or stroke.
  • This product is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using this drug when pregnant (see Eylea and Pregnancy).
  • It is not known if aflibercept passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Eylea and Breastfeeding).
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