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Aflibercept Side Effects

Common Side Effects

Aflibercept has been studied extensively. In these studies, some of the people were treated with aflibercept, while others were treated with ranibizumab (Lucentis®), a similar medication that is also injected into the eye. The side effects that occurred in the two groups were carefully documented and compared.
In these studies, the most common aflibercept side effects included:
  • Blood spots on the white part of the eye -- in up to 25 percent of people
  • Eye pain -- up to 13 percent
  • Increased pressure in the eye -- up to 8 percent 
  • Cataracts -- up to 7 percent
  • Vitreous detachment (a common and usually harmless eye change that can result in "floaters" in the vision) -- up to 6 percent
  • "Floaters" in the vision -- up to 6 percent.
Other common reactions, occurring in 1 to 5 percent of people, included:
  • Red eyes
  • Erosion of the cornea
  • Detachment of the retinal pigment epithelium (a common finding in people with macular degeneration)
  • Pain at the injection site
  • Feeling like something is stuck in the eye
  • Blurred vision
  • Watery eyes
  • Swelling of the eye or eyelid
  • Bleeding at the injection site
  • Retinal pigment epithelium tear (tears in certain eye tissue).

Final Thoughts

You may experience some or none of the aflibercept side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using aflibercept or if something "just does not seem right." While it may not be related to the medication, your healthcare provider should be able to diagnose and treat the problem.
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